I have a rule that I Will Not read livejournal/deadjournal from work, except in an emergency (urgent need to contact someone specific). Partly this is a security thing - the computer on my desk only has Internet Exploder 6 (yes, really), and I don't have permission to install anything less insecure. Partly it's to avoid the slippery slope where "I'm at work, so I must be working"; 2 hours later, still browsing the interwebs. I need to find out how to post to lj via email, because there have been a few things that I'd have liked to shoot off as quick posts in the middle of work.
My next problem is prioritising my work. At the moment I have several projects that are time-consuming, and I'm not sure what order to do them in. I need to:
- finish the GOLD tutorials (1-2 hours)
- finish making notes on GOLD from the manual (2-4 hours)
- make a load of notes on molecular modelling, with specific reference to genetic algorithms, from the modelling textbook o'doom (?? absolute guess, 20 hours? gods only know, really. But it'll be a while because it involves MATHS.)
- write up my notes on protein synthesis (5-10 hours? I understood it all, eventually, it's just a case of how neat I want to make things.)
- write up all the lectures I've attended in the protein folding classes (as long as a piece of string? uh... each lecture will take 2-4 hours to write up, longer if I consult the speaker's publications as I'll have to find them online and download them, and I've been to 7 of the 10 lectures so far. But I won't bother to write up the lectures that didn't mean a lot to me, such as the one in which all I learnt was "all of the textbooks currently in existence are wrong". So let's say 5 lectures x 5 hours as an absolute limit, and get 25 hours)
- find the correct crystallographic structures online for the protein I'm supposed to be using (1 hour, probably sitting in Philip's office. Not hard.)
- remove the ligands from the crystallographic protein structures (minutes) and define the protein binding site (uhh...)
- read all of the relevant papers about the Hsp90 binding site to make sure I get all the essential parts in! (30 minutes to many hours. I already know that there are 3 key hydrogen bonds, and could find a paper within minutes to confirm which residues are involved in those. But are there any other important quirks? Not sure.)
- make sure each protein binding site has the correct shape and all residues have the right tautomeric and protonation states (How long is a ROPE?)
- learn how to use whatever piece of software we're going to use to draw our ligands (no more than 5 hours)
- draw the ligands (20 minutes per ligand)
- optimise all the bond angles, conformations and energy states of the ligands (impossible to say. I have no idea how long the calculations would take.)
- dock the new ligands into the various protein binding sites (5 minutes per protein-ligand combination)
Clearly some of these things have to be done before some other of these things, that's easy enough. But I don't know what order to put the, er, groups of work into. I can't make a timetable where I work on something for a couple of hours then switch - that doesn't work with the whole being bipolar thing. (I can either concentrate, or not concentrate, there is no middle ground. If I am failing to make any headway at all on a project then I can switch to another piece of work and possibly even do very well at it; but if I am in the middle of work and highly focused, I can't switch to something else and expect to be able to get anything done. I believe this is similar to what some people experience with ADHD, but the meds that help with ADHD are totally contraindicated for bipolar).